Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses

Dextromethorphan and Its Metabolite Dextrorphan Block a3b4 Neuronal Nicotinic Receptors

Dextromethorphan (DM), a structural analog of morphine and codeine, has been widely used as a cough suppressant for more than 40 years. DM is not itself a potent analgesic, but it has been reported to enhance analgesia produced by morphine and nonsteroidal anti-inflammatory drugs. Although DM is considered to be nonaddictive, it has been reported to reduce morphine tolerance in rats and to be u...

Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance.

Dextromethorphan urinary metabolic ratio is widely used to determine the CYP2D6 phenotype, but its utility to reflect subtle differences in catalytic activity is unclear. We evaluated the capability of dextromethorphan urinary metabolic ratio to predict dextromethorphan oral clearance as a measure of CYP2D6 activity. Data from 10 healthy extensive metabolizers of CYP2D6 were given 30 mg of dext...

Full Title: Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance

Review: high doses of antipsychotic drugs are no more or less effective than medium doses in people with schizophrenia.

Study selection and analysis: Double blind, randomised controlled trials of people with schizophrenia or schizoaffective disorder comparing two or more doses of typical or atypical antipsychotics were eligible. Dose response curves were plotted and the median effective dose, defined as 50% of the maximum response (ED50), and the near maximal effective dose range (ED85 to ED95) was established f...

Door Allocations to Origins and Destinations at Less-than-Truckload Trucking Terminals

For an LTL (Less-than Truckload) carrier, the allocation of doors at a consolidation facility to outbound trailers assigned to various destinations, and to inbound trailers in the continuous stream arriving from various origins, has a significant impact on its operations, and on the nightly man-hours needed for consolidation. In the past literature door allocations to destinations of outbound t...